I am having a problem with an intramolecular cyclization reaction. For the reaction, I am mapping the reactive centers as two different molecules, then highlighting both molecules and selecting "Merge Reactants".
I then select the file with the input molecules, set it to enumerate sequentially, and then when I enumerate it creates zero products every time. I did the same exercise last year with no issue.
I am making fairly large and complex macrocycles, but I tested this also with a simple Williamson ether-type reaction and the same thing occurs - see screenshots below:
Is there an additional option I need to select to make an intramolecular reaction work or has this feature become broken?