User bd69837856
21-10-2010 11:09:22
In some cases where two tetrahedral stereocentres are adjacent to each other the "Remove Explicit Hydrogen" can remove one of the stereocentres.
I attach an example where this is the case - the stereocentre on the six membered ring is undefined after the remove explicit hydrogen has been perfomed. It looks like the cause is that the bond between the stereocentres is assigned to be a wedge hence making assigning appropriate wedge/hatch bonds to the other stereocentre problematic. Perhaps when assigning the wedge/hatch bonds, bonds that do not connect stereocentres could be favoured.