free energy of aqueous solvation

Is there some way to calculate the free energy of aqueous solvation for a series of compounds?

thanks

Hi,

We don't have method for calculating the "free energy of aqueous solvation".  May be  the next paper will help you.

Perspectives in Drug Discovery and Design: Volume 19, Number 1 / September ,2000, pages 85 - 98

"Abstract:  Methods for the calculation of two properties of interest in drug design, namely free energy of aqueous solvation and lipophilicity (log P), using fragmental methods are reviewed here."...

 

Jozsi

thanks a lot

 

yash