2D clean and stereochemistry

Hi

I've attached a before-2d-clean.mol and an after-2d-clean.mol that was created via MarvinSketch .NET 5.5.0.1. The stereochemistry of the bridgehead oxygen atom appears incorrect. Can anyone advise. Thanks

Hi,

I have moved this topic to the structure representation forum, my colleagues will answer for you soon.

Regards,
Istvan

Hi,

According to the chirality values (View->Stereo->R/S labels-> All) they are the same, before and after cleaning. (The descriptors are the same for the atoms before and after the cleaning.) However, I agree that it is really hard to see this (e.g. the carboxyl group is pointing downward).